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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Siyuan Wang

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2 papers indexed here

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Sep 2026

Mechanistically Informed Open-World Enzyme Retrieval with a Dual-Tower Graph-Sequence Model.

Identifying enzymes capable of catalyzing specific chemical transformations across large sequence databases remains a major challenge in biocatalyst discovery. Conventional fingerprint-based methods capture global molecular structure but fail to represent bond-breaking and bond-forming events, limiting generalization t...

Si-Yuan Wang, Dan Wang, Ying Ren et al. · 0 citations
Aug 2026

Co-evolution-guided engineering of monensin biosynthetic monooxygenase MonCI reveals mechanistic basis for concurrent stability and catalytic enhancement.

Improving enzyme stability without compromising catalytic activity remains a major challenge in protein engineering. Here, we present a co-evolution-guided strategy to enhance both thermostability and catalytic performance of the flavin-dependent monooxygenase MonCI, an enzyme involved in monensin biosynthesis. By comb...

Hongli Xiao, Jing Li, Jiajie Zhou et al. · 0 citations

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