Sivakumar Annadurai

Design of Quinazoline Dual Inhibitors Targeting Focal Adhesion Kinase and Polo-like Kinase 1 for Metastatic Cancers: QSAR, Pharmacophore Modelling, and Molecular Docking Approaches.

INTRODUCTION FAK and PLK1 are regulators of oncogenic signaling and metastasis, and their coinhibition offers a synergistic anticancer strategy. This study employed computational modeling to design quinazoline-based scaffolds as potential dual FAK-PLK1 inhibitors. METHODS 54 quinazoline derivatives were analyzed usin...