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Review Open access Oct 2026

Diabesity: an old term, a modern challenge — multi-omics and precision anti-obesity pharmacotherapy in type 2 diabetes

Evidence for approved and investigational oral incretin therapies, dual and triple receptor agonists, amylin-based strategies, established antidiabetic drugs, and adjunctive approaches targeting body composition are summarized.

Karolina Hoffmann, Weronika Pucek, Wiktoria Skrzypek et al. · 0 citations
Review Open access Aug 2026

CD44-Targeted Hyaluronic Acid Nanoparticles for Triple-Negative Breast Cancer: Recent Advances and Clinical Perspectives

Triple-negative breast cancer (TNBC) is a tough, heterogeneous subtype of breast cancer characterised by the absence of oestrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 expression, which results in limited therapeutic options and bad clinical outcomes. Several nanomedicine strategi...

S. Talath · 0 citations
Review Open access Sep 2026

Targeting the Gut–Bone Axis with Prebiotics, Probiotics, Synbiotics, and Postbiotics: From Mechanistic Plausibility to Clinical Bone Outcomes

Osteoporosis is a major skeletal disorder. Increasing evidence suggests that gut microbiota-derived mechanisms may contribute to bone remodeling. The biological rationale for a gut–bone axis is well supported, but the clinical relevance of microbiome-targeted interventions remains uncertain. In this narrative review, w...

Sorina Ispas, V. Maggio, A. Wali et al. · 0 citations
Review Open access Jan 2026

Microbiome‐Driven Mechanisms in Breast Cancer: Emerging Evidence From Gut Microbial Signatures to Therapeutic Response

Breast cancer remains the most frequently diagnosed malignancy among women worldwide, and increasing evidence indicates that the gut microbiome plays a significant role in tumor initiation, progression, and therapeutic response. Microbial dysbiosis and altered metabolite production have been associated with systemic in...

A. Wali, S. Talath, I. Rangraze et al. · 0 citations
Review Open access Sep 2026

Pathological Complete Response to Nab-Paclitaxel–Containing Neoadjuvant Regimens in Early Triple-Negative Breast Cancer: A Systematic Review and Meta-Analysis

Within nab-paclitaxel-containing neoadjuvant backbones, checkpoint-inhibitor addition was associated with higher pCR in randomized comparative evidence, and should not be interpreted as a cross-regimen comparison because of clinical and methodological heterogeneity.

R. A. Salama, M. El-Tanani, S. A. Rabbani et al. · 0 citations

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