Comparative in Silico Toxicological Assessment of 16 Selective COX-2 Inhibitors (Coxibs) Using Multi-Platform Predictive Models
Selective cyclooxygenase-2 (COX-2) inhibitors (coxibs) offer reduced gastrointestinal toxicity compared to traditional non-steroidal anti-inflammatory drugs (NSAIDs), yet their safety remains controversial as evidenced by several market withdrawals due to severe cardiovascular and hepatic risks. This study systematical...