Network analysis and species-specific siRNA design targeting MMP7 in feline chronic kidney disease
Chronic kidney disease (CKD) is a common acquired disorder in older cats and is associated with tubulointerstitial fibrosis, chronic inflammation, hypoxia, oxidative stress, and extracellular matrix (ECM) remodeling. Matrix metalloproteinase-7 (MMP7), a tubular epithelial-derived endopeptidase, has been implicated in r...