Open access
Aug 2026
Proteome-wide identification of the druggable CRBN interactome.
This pipeline identified 6 known and 43 novel CRBN-pomalidomide binders, including orthogonally validated hits that provide privileged starting points for MGD development, and expects this binding-focused workflow to be applicable to other MGD-E3 ligase systems, potentially extending the scope of this emerging drug cla...
Pius Galli, Shuhao Xiao, Y. Meng et al.
· Nature Biotechnology · 1 citation