Author

Simon Auslaender

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Open access Aug 2026

Assessing Codon Language Models for Context-Aware Codon Optimization in Nucleic Acid-Based Medicines

In vitro data showed that MLM-designed variants outperformed conventional and commercial-vendor-derived sequences in both transient and stably integrated expression, supporting the models’ ability to capture translational context beyond codon frequency.

Shushan Toneyan, Kerstin Scholz, C. de Donno et al. · bioRxiv · 0 citations