Open access
Jul 2026
Discovery of a Dual IDO1/TDO Inhibitor That Modulates Enzymatic Activity and IDO1/SHP‑2 Signaling
Compound 66 represents a chemical probe for dissecting enzymatic and signaling functions within the IDO1/TDO axis and supports small-molecule modulation of both catalytic and noncatalytic immune-metabolic pathways as an alternative to purely catalytic IDO1 inhibition or complete IDO1 degradation.
Sarah Jane Rezzi, Andrea Butticè, Salvatore Villani et al.
· Journal of Medicinal Chemist... · 0 citations