This Review critically evaluates CD38 biology, Fc-mediated immune-effector mechanisms, immune remodeling, clinical evidence, resistance, safety, laboratory interferences, biomarker evidence, and clinical positioning of anti-CD38 antibodies, with multiple myeloma as the central reference disease.
Li-Ming Yu, Chang-Nian Li, Da-Dong Guo et al.· Frontiers in Immunology· 0 citations
Lung and prostate cancers were the most common OPMs in this cohort, highlighting the need for heightened clinical attention to these malignancies in patients with MM.
Chang-Nian Li, Ya-Ru Wang, Lu-Lu Li et al.· Frontiers in Oncology· 0 citations
Overall, ASH 2025 suggests a shift from achieving gene editing to quantifying efficacy, durability, and safety, with standardized biomarker frameworks likely to play an increasingly important role in future clinical translation.