Author

Si-Yu Chen

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Sep 2026

Attenuation of Vascular Cognitive Impairment by Panaxadiol Through Promoting Hippocampal Angiogenesis in a Chronic Cerebral Hypoperfusion Model.

OBJECTIVE This study explores the therapeutic efficacy and mechanisms of panaxadiol (PD), a ginseng-derived sapogenin, in a mouse model of vascular cognitive impairmentinduced by chronic cerebral hypoperfusion (CCH). METHODS CCH was induced in C57BL/6 mice by bilateral common carotid artery stenosis (BCAS). Mice were...

Xing-Yu Bai, Yong-Xin Ma, Shuang Wang et al. · Experimental Aging Research · 0 citations

Oct 2026

Low-dose radiotherapy ameliorates Alzheimer's-like pathology in 5xFAD mice and is associated with HIF-1α-related inflammatory signaling downregulation.

BACKGROUND Whether fractionated low-dose radiotherapy (LDRT) alleviates Alzheimer's disease-like pathology and whether these effects are associated with microglial HIF-1α-related signaling remain unclear. METHODS Male 5xFAD mice received whole-brain irradiation at 2 Gy per fraction for 5 fractions (total dose, 10 Gy)...

Hong-Tao Jiao, Hao Huang, Si-Yu Chen et al. · Pathology, Research and Prac... · 0 citations