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Sep 2026

Top-Down Proteomics Analysis of pg-Level Cell Lysate Using Spray-Capillary CE-FAIMS-MS

Capillary electrophoresis-mass spectrometry (CE-MS) is a promising technique for ultrasensitive top-down proteomics due to its high resolution and sensitivity compared with traditional liquid chromatography (LC)-based methods. However, CE-MS-based top-down proteomics of mass-limited samples remains challenging becaus...

Samina Anjum, Zhi-Tao Zhao, Kellye A. Cupp-Sutton et al. · 0 citations
Open access Sep 2026

ProteoformTracker: an interactive tool for planning proteoform detectability in top-down and middle-down proteomics

Summary Characterizing proteome complexity in disease contexts is essential for understanding molecular mechanisms and advancing therapeutic development. Mass spectrometry (MS)-based top-down and middle-down proteomics (TDP/MDP) can resolve intact proteoforms — protein molecules carrying a unique combination of isoform...

Araf Mahmud, Zhi-Hao Zhang, Si Wu et al. · 0 citations

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