Si-Si Zhou

Targeted Lactic Acid Regulation via Engineered Exosomes for Synergistic Metabolic and Photodynamic Tumor Therapy.

This work engineer an exosomal nanoplatform, PpIX/siRNA@EXO-LOD, to simultaneously disrupt intra- and extracellular LA homeostasis, thereby enabling synergistic metabolic and photodynamic therapy (PDT) and demonstrates that this dual-regulation strategy effectively inhibits tumor growth, downregulates metastasis-related factors, and reprograms the TME from an immunosuppressive state to an immunologically active state.