Ferroptosis-Targeted Strategies to Counter Hypoxia- and Acidosis-Associated Immunosuppression in the Tumor Microenvironment.
Immunotherapy has transformed cancer treatment, yet its efficacy in solid tumors remains constrained by primary or acquired resistance. Increasing evidence suggests that ferroptosis sensitivity is shaped not only by tumor intrinsic metabolic programs but also by the surrounding microenvironment. Ferroptosis, an iron-de...