Sep 2026
MMSDH facilitates ACSL4 propionylation to counteract ferroptosis upon hypoxia and impairs PDAC chemotherapy efficacy.
Pei-Xiang Zheng, Yan-Ni Lin, Mei-Yin Zhang et al.
· Nature Cancer · 0 citations
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Review
Open access
Jul 2026
Tumor heterogeneity: development, mechanisms, and therapeutic implications
This review synthesizes key advances in understanding tumor heterogeneity: from its cellular origins and molecular mechanisms to its multidimensional manifestation in the tumor microenvironment and from metastatic heterogeneity to the fundamental causes of treatment resistance.
Jianhong Zhang, Heng Li, S. Ru et al.
· Signal Transduction and Targ... · 1 citation