Shuo-Han Ning

TSC1-mTORC1 signaling in Alzheimer’s disease: an integrated bioinformatic analysis linking gene expression to neuropathology

Integrated human data provide compelling evidence that TSC1 deficiency is a hallmark of AD and is associated with mTORC1 hyperactivation, aggravated amyloid-tau pathologies, cognitive impairment, and neuroinflammation, consistent with a model in which TSC1 deficiency and mTORC1 hyperactivation may contribute to AD path...