K+-Selective Compaction of Flexible Ionophore PF1022A: Conformational Landscapes of Alkali Metal Complexes.
The natural cyclic octadepsipeptide ionophore PF1022A (PFA) selectively transports physiologically relevant K+ over Na+ across lipid membranes; however, its underlying structural mechanism remains unclear. Here, variable-temperature ion mobility mass spectrometry and theoretical calculations revealed the conformational...