Open access
Sep 2026
IDH3-dependent mitochondrial function in stromal fibroblasts suppresses malignant tumor growth.
Malignant solid tumors comprise not only cancer cells but also diverse non-cancerous stromal cells that shape the tumor microenvironment. The tricarboxylic acid (TCA) cycle has an overarching presence in providing substrates needed to drive the electron transport chain and, ultimately, ATP synthesis. However, it remain...
L. R. Koseki, Minoru Kobayashi, Mai Ito et al.
· Neoplasia · 0 citations