Tailoring lipid nanoparticles for application-specific mRNA delivery.
This study proposes an application-oriented re-engineering strategy that leverages the clinically validated SM-102 platform, enabling rational LNP optimization for diverse mRNA delivery and therapeutic scenarios and recommends SM-102/DSPC and SM-102/DOPE LNPs as preferred formulations for RAW 264.7 macrophages and IGRO...