Coptisine Protects Against Cisplatin-Induced Acute Kidney Injury With Involvement of PI3K/Akt Signaling.
Cisplatin is an effective chemotherapeutic agent whose clinical use is limited by nephrotoxicity. This study investigated the protective effects of coptisine, a bioactive alkaloid from Coptis chinensis, against cisplatin-induced acute kidney injury (AKI). Network pharmacology was used to predict potential targets and p...