Author

Shuji Ogino

3 papers indexed here

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Open access Oct 2026

Insights into early-onset colorectal cancer from a single-nucleus RNA-seq atlas of colorectal cancer across the age continuum.

The incidence of early-onset colorectal cancer (EO-CRC; diagnosed before age 50 years) is increasing worldwide. Although current data indicate that EO-CRC may be biologically distinct from average-onset CRC (AO-CRC; diagnosed at age ≥50 years), molecular differences remain poorly defined. To address this knowledge gap,...

Caroline B. M. Porter, Shane P. Murphy, Jules Cazaubiel et al. · Nature Medicine · 0 citations

Open access Oct 2026

Identification of prediagnostic proteomic biomarkers for colon and rectal cancer in 3 prospective cohorts.

It is found that pre-diagnostic plasma proteomics identified proteins and pathways with modest effect sizes and clear differences between future risk of colon and rectal cancer and motivate site-specific biomarker discovery that distinguishes colon from rectal cancer.

Xin-Yuan Zhang, Jonathan M. Downie, D. Drew et al. · Journal of the National Canc... · 0 citations

Review Oct 2026

Tumor-Immune Microenvironment of Early-Onset Colorectal Cancer: Implications for Immune-Based Prevention and Therapy.

This review synthesizes current evidence on the TiME of EOCRC and contrast it with that of conventional LOCRC, and explores how these insights inform immune-based prevention and immunotherapy strategies, including checkpoint blockade and rational combinations in the predominant microsatellite-stable EOCRC population.

José Perea, María González-Sanmartín, M. Coiras et al. · Cancer immunology research · 0 citations