Author

Shuichi Hoshika

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Open access Sep 2026

Structural basis of transcription of the hachimoji eight-letter alphabet by E. coli RNA polymerase

It is shown that bacterial RNA polymerase faithfully transcribes an eight-letter genetic alphabet and recognises unnatural base pairs through mechanisms similar to those used for natural DNA.

Qing-Rong Li, Hyo-Joong Kim, Yan Liu et al. · Nature Communications · 0 citations