Shui-Jie Li

Icariin synergistically inhibits glycolysis and mitochondrial energy metabolism in lung cancer in association with the HIF-1α/LONP1 axis.

AIM OF THE STUDY Non-small cell lung cancer (NSCLC) accounts for the vast majority of lung cancer cases and remains a therapeutic challenge due to drug resistance, adverse effects, and metabolic plasticity. Icariin (ICR), a principal bioactive flavonoid from Epimedium, exhibits promising antitumor properties; however,...

Epidermal growth factor receptor activation is associated with NSCLC cells resistance to ferroptosis and correlates with ROS-NRF2-GCLC/GCLM pathway activation.

Mutations of epidermal growth factor receptor (EGFR) closely correlate with differential ferroptosis sensitivity in select cell lines, but the underlying mechanism is poorly understood. In this study, we identified the epidermal growth factor (EGF)-activated EGFR as a correlate of ferroptosis suppression in non-small c...

CFTR regulates lipid metabolism by relieving adipose inflammation in obesity.

Sodium tanshinone IIA sulfonate attenuates pulmonary vascular remodeling by targeting DYRK1A in pulmonary hypertension.

BACKGROUND Pulmonary hypertension (PH) is a progressive disorder marked by elevated pulmonary artery (PA) pressure and vascular remodeling, often leading to right heart failure. A key feature is pulmonary artery smooth muscle cells (PASMC) phenotypic switching from a contractile to a synthetic state, which drives media...

USP15-mediated deubiquitination of FIS1 impairs mitochondrial function and sensitizes bladder cancer cells to radiotherapy

USP15 plays a critical role in regulating radiosensitivity, and targeting USP15-mediated mitochondrial OXPHOS may represent a promising therapeutic strategy to enhance the efficacy of radiotherapy in bladder cancer, providing a novel treatment approach for the treatment of bladder cancer patients.