The versatile TRAF3 from sea urchin (Strongylocentrotus intermedius) interacts with MyD88 and regulates host immunity.
SiTRAF3 is identified as a pivotal scaffold protein in the echinoid innate immune system, as it significantly drove the promoter activities of nuclear factor kappa-B, activator protein-1, signal transducer and activator of transcription 3, along with multiple inflammatory cytokines and interferon-related elements.