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Author

Shuang Song

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Open access Sep 2026

Engineering the chimeric lysin Art-15 via NZ2114–PlySs2 fusion enhances strain-specific antibacterial activity

The global rise of multidrug-resistant Gram-positive pathogens demands new antimicrobial strategies. Phage-derived endolysins such as PlySs2 show promising cell-wall targeting activity but may be limited by strain-dependent cell-envelope accessibility. We engineered Art-15, a chimeric lysin that fuses the lipid II-targ...

Meng-Lin Lee, Zhi-Tao Wu, Xing-Yu Zhou et al. · 0 citations

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