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Open access Sep 2026

AI-enabled multi-omics pharmacogenomic modeling guides resistance-aware multitarget optimization of venetoclax therapy in acute myeloid leukemia

Acute myeloid leukemia (AML) remains difficult to treat because profound molecular heterogeneity enables rapid adaptive resistance to targeted therapy. We developed an AI-driven pharmacogenomic pipeline that integrates genomic, transcriptomic, epigenetic, and clinical features to predict patient-specific response to ve...

Chen Wang, Zhi-Jie You, Si-Qi Chen et al. · 0 citations

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