HSF1-UCHL1 transcriptional axis protects against MASLD via regulation of PPARα protein stability.
BACKGROUND & AIMS Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the most prevalent chronic liver diseases in modern society. Heat shock factor 1 (HSF1) is a transcription factor that orchestrates cellular responses and closely associate with metabolic diseases. However, the specific hepatic...