Author

Shuang Li

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Open access Aug 2026

Drug sensitivity prediction across cancer types using graph isomorphism networks and biological pathway features: A dual-branch deep learning approach

An innovative dual-branch approach based on Graph Isomorphism Network drug representations coupled with a Multilayer Perceptron (MLP) for 50-dimensional ssGSEA pathway activities calculated from CCLE gene expression is proposed, proving the importance of biological features in the two-branch model.

Shuang Li, Quanzhong Yang, Feifei Shen et al. · PLoS ONE · 0 citations