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Shuang-Jun He

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Open access Oct 2026

SENP3-mediated deSUMOylation of PINK1 suppresses mitophagy and aggravates lipopolysaccharide-induced acute lung injury

Mitochondrial dysfunction triggers excessive reactive oxygen species (ROS) accumulation, which greatly exacerbates acute lung injury (ALI). Mitophagy, a cellular mechanism for maintaining mitochondrial homeostasis, is crucial to the progression of ALI. SENP3 is a redox-sensitive SUMO2/3 protease that is pivotal i...

Shuang-Jun He, Chen-Yu Fan, Chun-Yan Guo et al. · 0 citations
#protein folding Open access Sep 2026

A universally conserved OMV-YidR conjugate nanovaccine confers broad protection against hypervirulent and carbapenem-resistant Klebsiella pneumoniae

ABSTRACT The escalating crisis of multi-drug resistant (MDR) Klebsiella pneumoniae (KP) renders standard antibiotic treatments increasingly ineffective, necessitating a shift towards alternative approaches like vaccination. However, the development of a broadly protective vaccine remains hindered by the pathogen's exte...

Shuang-Jun He, Yang Zhang, Ahui Song et al. · 0 citations

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