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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Shuang Chen

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Open access Oct 2026

Structure-Guided Design of a Subnanomolar Dengue Virus NS4B Inhibitor.

Dengue virus nonstructural protein 4B (NS4B) is an essential regulator of viral replication but remains structurally unresolved, limiting drug discovery. Here, we combine modeling, ligand-based design, and experimental validation to enable structure-guided inhibition of NS4B. Comparative models across all four serotype...

Poomipat Laorsatiankul, Mohammad Hassan Baig, Shuang Chen et al. · 0 citations

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