Shuai Yan

Nuclear cGAS inhibits stimulation-induced inflammatory gene transcription via HDAC1.

Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that detects aberrant DNA and activates the STING-dependent innate immune response. Although cGAS is predominantly localized in the nucleus under physiological conditions, its nuclear function remains incompletely understood. Here, we identify nuclear cGAS as a t...

A Combined Network Toxicology and Docking Study to Identify Putative Molecular Targets Linking Styrene Exposure to Atherosclerosis.

Construction of naringenin-loaded chitosan/sodium alginate nanocomposite gels and their controlled-release kinetics in simulated gastrointestinal media

Naringenin has gastrointestinal pharmacological potential, but poor aqueous solubility, rapid crystallization and limited intestinal residence constrain oral formulation performance. This study evaluated whether coupled tripolyphosphate (TPP) and calcium-ion gelation could produce chitosan/sodium alginate (CS/ALG) nano...

Spatiotemporally Resolved Tracking of Extracellular Vesicle Cargo via Photocatalytic Extracellular Vesicles Protein Tracking (PhoEVT)

Extracellular vesicle (EV)‐mediated protein transport has been recognized as a crucial mechanism for intercellular communication and interaction. Proximity labeling has emerged as a promising approach to study the dynamic protein interactions in cellular activity, but tracking extracellular protein transport pathways r...