Author

Shuai Li

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Open access Oct 2026

Genome-wide mapping of endogenous topoisomerase cleavage complexes reveals TOP1 at the interface of DNA topological regulation and genome instability

Topoisomerase cleavage complexes (TOPcc) are covalent protein–DNA intermediates formed transiently during topoisomerase catalysis and constitute a major class of DNA–protein crosslinks in human cells, yet their endogenous genomic distributions remain difficult to resolve. Here, we developed protein–DNA adduct immunopre...

Shuai Li, Chong-Yi Chen · bioRxiv · 0 citations

Open access Oct 2026

Topoisomerase-mediated resolution of negative DNA supercoiling sustains human transcription and gene activation

Transcription generates DNA supercoiling that can influence gene expression, but how transcription-associated supercoiling shapes RNA polymerase II (RNAPII) dynamics in human cells remain poorly understood. Here, we show that topoisomerase-mediated resolution of negative DNA supercoiling is required for productive tran...

Jun Lyu, Abdelmonsif Ahmed, Ipsita Biswas et al. · bioRxiv · 0 citations