Linear Fitness Subspace in Protein Language Models Enables Sample-Efficient Directed Evolution
Model-guided directed evolution seeks to identify high-fitness protein variants under limited oracle budgets. Protein language models (PLMs) provide rich representations for this task, but task-agnostic zero-shot scores can be misaligned with a target assay, while supervised search in high-dimensional embedding spaces...
Si-Yuan Ma, Can-Ran Xiao, Zi-Kai Xiao et al.
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