Author

Shu-Yi Si

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Oct 2026

A synthetic cationic thiopyrylium compound exploits preferential phosphatidylserine recognition to exert antifungal activity.

Findings reveal a mechanism of action in which preferential binding to PS dysregulates fungal lipid homeostasis rather than lysing the membrane, and define IMB-G3 as a promising lead compound for a novel class of antifungal therapeutics.

Bing-Chen Li, Jing Zhang, Shu-Yi Si et al. · Bioorganic chemistry (Print) · 0 citations

Open access Aug 2026

A Novel Cell-Based High-Throughput Screening Model for Inhibitors Targeting Influenza Virus Hemagglutinin–α-2,6-Sialic Acid Interaction

This subtype-independent, highly specific high-throughput screening (HTS) model provides an efficient and reliable platform for early-stage influenza drug discovery and lead compound development.

Ke-Yu Guo, Xiao-Fang Chen, Chen-Yin Wang et al. · Biomolecules · 0 citations