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Author

Shu-Xin Sun

2 papers indexed here

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Sep 2026

circMTHFD1L-driven lipid metabolism in Cancer-associated fibroblasts confers oxaliplatin resistance in pancreatic cancer through O-GlcNAcylation-dependent chromatin recruitment of Ku70.

Platinum-based chemotherapy resistance severely limits therapeutic efficacy and survival in pancreatic ductal adenocarcinoma (PDAC), yet the role of cancer-associated fibroblasts (CAFs) in driving this resistance remains elusive. We screened and validated circMTHFD1L (hsa_circ_0078269) as a stromal circRNA that is mark...

Qing Tian, Tian-Hao Huang, Ning-Ning Zhang et al. · 0 citations
Aug 2026

Integrin β6-Targeted CAR-T Cells exhibit potent antitumor activity in β6-Positive pancreatic ductal adenocarcinoma and lung adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) and lung adenocarcinoma (LUAD) remain lethal malignancies with limited therapeutic options, highlighting an urgent need for more effective treatments. Integrin αvβ6 (ITGB6) is a receptor preferentially expressed in specific types of tumors, such as PDAC and LUAD, and represents a...

Ling-Chao Shi, L. Qin, Shu-Xin Sun et al. · 0 citations

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