p21 Inhibition Rescues Radiation-Induced Osteogenic Dysfunction and Promotes Bone Regeneration in Osteoradionecrosis of the Jaw via the Rb-Smad2/3-Runx2 Axis.
BACKGROUND Osteoradionecrosis of the jaw (ORNJ) is a severe radiotherapy complication with unclear molecular drivers. CDKN1A/p21 is upregulated by radiation-induced DNA damage, but its role in ORNJ remains unknown. METHODS An ORNJ mouse model was established. Single-cell RNA-sequencing of irradiated mandibles was ana...