Shu-Qiang Yang

Epitranscriptomic RNA modifications in cancer DNA damage response: mechanistic links between RNA fate, genome maintenance, and therapy resistance

Epitranscriptomic RNA modifications have emerged as a fundamental regulatory layer linking RNA metabolism with genome maintenance, DNA damage response (DDR), and therapeutic resistance during cancer evolution. Throughout tumorigenesis, persistent oncogenic signaling, replication stress, oxidative stress, metabolic re...