An Uncertainty-Guided Digital Twin Framework for Online Adaptive Proton Therapy in Head and Neck Cancer: A Feasibility Study
Objective: Head and neck (HN) proton therapy spans six to seven weeks of anatomical change, while offline replanning takes about a week. We present an uncertainty-guided digital twin (UGDT) framework that forecasts treatment-day anatomy before treatment and evaluate whether it generates online adaptive proton therapy (...
Yi-Zhou Wu, R. Sanford, Hui-Qiao Xie et al.
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