Rational design of a near-infrared fluorescent probe for highly specific sensing carboxylesterase 2 and its applications in bioimaging.
Carboxylesterase 2 (CES2) is a clinically significant serine hydrolase that governs the metabolic activation and detoxification of numerous ester-containing drugs and prodrugs. Despite its pivotal role in liver and colorectal cancer progression, direct in situ imaging of CES2 activity remains challenging due to the sca...