Targeting the crosstalk between histone methyltransferases G9a and EZH2 represents a promising strategy for cancer therapy. To improve upon our previously reported dual inhibitor SU08, we rationally designed and synthesized five series (SU, UA, UB, N, and L) of novel G9a/EZH2 dual inhibitors, incorporating diverse pyri...
Introduction Astragalus, as a traditional tonic herb, has alycosin-7-O-β-D-glucoside as one of its main active components. Methods In this study, a strain of Lactobacillus helveticus HP-B1137 was isolated from raw milk in Mudan District, Heze City, Shandong Province. The probiotic properties, and ability to biotransfor...
Shu-Hang Zhang, Lan-Fang Li, Zhao-Sen Fan et al.· Frontiers in Microbiology· 0 citations
The whole-genome sequencing and functional annotation of Lacticaseibacillus rhamnosus HP-B1083 reveal that this genome is rich in genes related to carbohydrate metabolism, hydrolases, and transferases, which is highly consistent with its phenotypic characteristics in glycoside transformation and the synthesis of antiba...
Da-Hu Zhang, Zhen-Dong Tian, Bao-Zhi Ge et al.· Brazilian Journal of Microbi...· 0 citations
This work provides the first evidence of GldL glycosylation and establishes its critical role in T9SS function, and offers a novel perspective for elucidating cellulose degradation in C. hutchinsonii.
Wenxia Song, Zizhe An, Shu-Hang Zhang et al.· International Journal of Bio...· 0 citations
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