Biomimetic PLGA nanoparticles-mediated low-intensity pulsed ultrasound-triggered targeted release of C646 for esophageal cancer therapy.
Esophageal squamous cell carcinoma (ESCC) is associated with high morbidity and poor clinical prognosis among the Chinese population. Conventional chemoradiotherapy is hampered by severe systemic toxic effects and inadequate tumor-targeting performance. EP300 represents a promising epigenetic therapeutic target for ESC...