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Shruti Gupta

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Review Open access Jul 2026

From Selfish Transposon Enzymes to Programmable Miniature Genome Editors: The Biology, Evolution, and Engineering of TnpB Nucleases

The principal challenges, including transposon-associated motif (TAM) restriction, off-target activity, delivery and mechanistic understanding, that must be addressed are outlined before the therapeutic and agricultural potential of TnpB-derived technologies can be fully realised.

Sanchit Pal Singh, Shruti Gupta, Rohit Solanki et al. · 0 citations

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