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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Shou-Zhi Chen

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Open access Sep 2026

UpTCR: a unified progressive knowledge transfer foundation model for robust T-cell receptor-antigen binding recognition

T-cell receptor (TCR) recognition of antigenic peptides presented by human leukocyte antigen (HLA) molecules underpins adaptive immunity and T cell-based immunotherapy. However, the scarcity of complete interaction data and TCR cross-reactivity challenge robust prediction. Here, we present UpTCR, a unified progressiv...

Tian-Xu Lv, Yang Xiao, Li Chen et al. · 0 citations
Aug 2026

DiConSite: A Unified Topology-Adaptive Architecture for Protein Binding Site Prediction Across Ligand Modalities.

By combining protein language model embeddings with topology-adaptive geometric reasoning, DiConSite offers a reusable framework for residue-level protein interaction analysis and achieves consistently strong and often best-performing results, while improving robustness to structural uncertainty and cross-modal variati...

Shou-Zhi Chen, Zhen-Chao Tang, Lin-Lin You et al. · 1 citation

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