Open access
Aug 2026
AAV-DJ enables efficient, function-preserving neuronal transduction for circuit interrogation in human cortical and thalamic organoids.
A capsid-dependent trade-off between transduction efficiency and functional integrity is revealed and AAV-DJ is identified as an optimal serotype for robust gene delivery and physiological interrogation in organoid-based neuroscience.
Shota Adachi, Masatoshi Nishimura, Kosuke Yamaguchi et al.
· Cell Reports Methods · 0 citations