Open access
Aug 2026
MYCN reprograms postnatal cells toward embryonic-like transcriptional states and drives tumorigenesis.
The embryonic-like features of neuroblastoma are commonly explained by a developmental arrest model, in which neural crest-derived progenitors undergo transformation after failing to complete normal sympathoadrenal differentiation. Whether such features can instead be actively imposed on postnatal cells during tumor de...
Y. Nakatsukasa, Michitada Hirano, Yosuke Yamada et al.
· Biochemical and Biophysical... · 0 citations