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Author

Shirui Pan

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Book Open access Aug 2026

Natural Language-Powered Functional Protein Sequence and Structure Co-Design with Multi-Modal Knowledge Fusion

This work proposes a Protein sequence–structure–function Consistency Design model empowered by Natural Language function description, dubbed ProtcdNl, which expands the protein design space and ensures alignment with function-aware framework, achieving the design of novel, diverse proteins with high functional fidelity...

Ming Yang, Xin Zheng, Yi Li et al. · 0 citations
Conference Sep 2026

TTS-Design: Test-Time Compute Scaling for Structure-Guided Protein Design

TTS-Design is proposed, a test-time compute scaling framework that enhances protein sequence design without retraining models or relying on larger training datasets, and can consistently improve sequence recovery and structural reliability across different backbone models, without retraining or increasing model size.

Zizhe Jin, Yi Zheng, Huan Yee Koh et al. · 0 citations

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