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Open access Dec 2026

Reproductive Lifespan and Hormonal Therapy in Relation to Later-Life Neurovascular Health in Community-Dwelling Older Women.

BACKGROUND AND OBJECTIVES Women are disproportionately affected by Alzheimer disease (AD), a vulnerability that may relate to estrogen fluctuations across the lifespan. Estrogen has neuroprotective and vasoprotective effects, suggesting that lifetime estrogen exposure may influence both AD-related neurodegeneration and...

Giulia Lorenzon, Gemma García-Lluch, G. Coughlan et al. · 0 citations
Open access Nov 2026

Healthy Sleep Mitigates the Association Between Cardiometabolic Disease and Poorer Cognitive and Brain Health.

BACKGROUND Cardiometabolic diseases (CMDs), including type 2 diabetes, heart disease, and stroke, are important risk factors for dementia. We examined whether healthy sleep can support cognitive and brain health in people with CMDs. METHODS The study included data from 408 977 adults from the UK Biobank. CMDs were de...

Yu-Yang Miao, Livia Fingerson, Elizabeth R. Walters et al. · 0 citations
Open access Sep 2026

Insomnia symptoms and stress exposure interact in relation to Alzheimer’s disease biomarkers

It is suggested that chronic stress and sleep disturbances exhibit an interactive relationship in their associations with AD pathology, and the need for further research into interactive effects of multiple modifiable risk factors in the development of AD is highlighted.

J. Holleman, I. Kåreholt, Manasa Shanta Näsholm et al. · 0 citations

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