AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
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An ensemble-based model in which pre-existing conformational organization shapes how the protein responds to the matched mutations is supported and stability-engineering mutations should be evaluated in the context of the parent ensemble is argued.
Intrinsically disordered proteins (IDPs) form biomolecular condensates through weak multivalent interactions, but the ensemble variables that control condensate stability and material properties remain incompletely defined. Most current descriptions emphasize sequence features or mean single-chain descriptors, such a...
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