Multiomics identifies the endothelial SYNPO2/VNN1 axis as a therapeutic target and validates a microbiota-directed vaccine in atherosclerosis
Gut microbiota (GM) dysbiosis is implicated in atherosclerosis (AS), but its causal mechanisms and actionable therapeutic targets remain elusive. This study aims to identify specific GM-host interactions and translate multiomics findings into clinically relevant therapeutic strategies. We developed an in...