Shinn-Ying Ho

TargetPrior: a miRNA-signature embedded evolutionary learning framework for prioritizing drug targets in acute myeloid leukemia

Abstract Motivation Prioritizing therapeutic targets from high-dimensional transcriptomic profiles is hindered by the underdetermined nature of the p ≫ n setting. While miRNA signatures can inform target prioritization, conventional accuracy-driven methods may yield unstable predictive signatures, reducing downstream n...