Open access
Oct 2026
Dibucaine induces autophagic flux and reduces Ser129-phosphorylated α-synuclein in induced pluripotent stem cell–derived neurons with SNCA duplication
The accumulation of α-synuclein (α-syn) in the form of Lewy bodies and Lewy neurites is a neuropathological hallmark of Parkinson’s disease (PD) and is closely associated with disease progression. Targeting the autophagy pathway to enhance the clearance of α-syn aggregates therefore represents a promising therapeutic...
M. Kitagawa, Kengo Miyamoto, Kozo Yoshida et al.
· Frontiers in Neurology · 0 citations